cov150hCell 160: 339-350  (January 15, 2015)

Just reading the first couple of pages of this article by Zalatan et al. (excerpted below), note how sophisticated, complex, powerful, inspiring, etc. our cellular machinery is — and all produced by naturalistic, unguided, entropy-producing processes! Really? Do you honestly believe that?

The abstract of the article can be found online.  If you can go to the full article you will find one-dimensional drawings that attempt to show what is a vastly more complex process than we, utilizing a lot of money for research done by our finest minds, in our elaborate laboratories, can only, at best study and emulate.  But anything we produce to imitate what our Creator and Lord has given, is clumsy and a cheap imitation of the original.

You who have even a modicum of common-sense, or minimal education know it is absurd to claim that cheap imitations are clearly designed, but the highly complex life forms we study and try to replicate in the lab are merely an accidental fluke of nature.

This article is just one of thousands such articles, whereby we mere mortals probe the complexities of life at the microscopic level, and no one can claim they are looking at SIMPLE life forms.   Yet the lead ceiling of indoctrination, brain-washing, or even fear to stand up and speak the obvious, that Emperor Evolution has no clothes to cover his frame, makes even our academic elite, blind to the wonder of God’s hand on creation..  And so the ruling paradigm goes largely unchallenged.  The utterly simplistic, absurd and impossible just-so stories that we’re all here because complex life forms just evolved, up from the lifeless slime, and just kept pulling up their little sockies, mindless though they were at first, and just by accident, and luck and…………….well any story will do as well as any other.  They are all absurdly simplistic scenarios that have never been seen in the lab, fly in the face of what we really know about physics, chemistry and biology.  Evolution requires billions and billions of miracles, and the biggest requirement is TIME, endless time, as much as the latest guru demands.  Time so vast that the stories can never be tested, never possible to authenticate, out of reach of the demand of real science, that being, – testable, repeatable, verifiable, falsifiable.

Evolution is a religion.  Woe betide any man or woman of science who dares to break the faith.

The RED emphasis and the underlining in the excerpt below is mine. – Gerda

Eukaryotic cells achieve many different states by executing complex transcriptional programs that allow a single genome to be interpreted in numerous, distinct ways. In these programs, specific loci throughout the genome must be regulated independently. For example, during development, it is often critical to activate sets of genes associated with a new cell fate while simultaneously repressing sets of genes associated with a prior or alternative fate. Similarly, environmental conditions often trigger shifts in metabolic state, which requires activating a new set of enzymes and repressing other previously expressed enzymes, leading to new metabolic fluxes. These complex multi-locus, multi-directional expression programs are encoded largely by the pattern of transcriptional activators, repressors, or other regulators that assemble at distinct sites in the genome. Reprogramming these instructions to produce a different cell type or state thus requires precisely targeted changes in gene expression over a broad set of genes. 

How might we engineer novel gene expression programs that match the sophistication of natural programs? Such capabilities would provide powerful tools to probe how changes in gene expression programs lead to diverse cell types. These tools would also provide the ability to engineer more sophisticated designer cell types for therapeutic or biotechnological applications. Although a number of transcriptional engineering platforms have been developed, there are major constraints for constructing complex transcriptional programs. . . . [p. 339]

To develop a platform for synthetic genome regulation that allows locus-specific action, we took inspiration from natural regulatory systems that encode both target specificity and regulatory function in the same molecule. [p. 340]

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